ea0025oc2.5 | Steroids | SFEBES2011
Parajes Silvia
, Kamrath Clemens
, Rose Ian
, Taylor Angela
, Mooij Christiaan
, Dhir Vivek
, Grotzinger Joachim
, Arlt Wiebke
, Krone Nils
Cytochrome P450 side-chain cleavage enzyme (CYP11A1) catalyses the first and rate-limiting step of steroidogenesis, facilitating conversion of cholesterol to pregnenolone. Cholesterol, transported by steroidogenic acute regulatory protein (StAR) into the inner mitochondrial membrane, is converted by CYP11A1 into 22R-hydroxycholesterol. Subsequently, CYP11A1 converts 22R-hydroxycholesterol by 20alpha-hydroxylation and cleavage of the C20C22 bond into pregnenolone. All pat...